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Related Concept Videos

Acne Infection01:27

Acne Infection

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Accessory Structures of the Skin: Sweat Glands01:20

Accessory Structures of the Skin: Sweat Glands

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Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
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Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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The Skin Microbiota01:27

The Skin Microbiota

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The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
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Related Experiment Video

Updated: Apr 10, 2026

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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Acne vulgaris.

Ertuğrul H Aydemir1

  • 1Department of Dermatology, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey.

Turk Pediatri Arsivi
|June 17, 2015
PubMed
Summary

Acne vulgaris is a common inflammatory skin condition affecting the pilosebaceous unit. Effective treatment involves patient-physician communication and can include topical or systemic therapies, with results typically seen in about six months.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit, affecting all sexes and races, typically starting at puberty.
  • While genetic predisposition is a key factor, the roles of androgens, cosmetics, and diet are limited.
  • The pathogenesis involves increased sebum excretion, follicular keratinization, bacterial colonization, and inflammation.

Purpose of the Study:

  • To provide a comprehensive overview of acne vulgaris, including its pathogenesis, clinical presentation, and treatment modalities.

Main Methods:

  • Review of existing literature on acne vulgaris.
  • Discussion of the multifactorial pathogenesis of acne.
  • Overview of current topical and systemic treatment options.
Keywords:
Acne vulgarisetiologytreatment

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Main Results:

  • Acne lesions, starting as comedones, can progress to papules, pustules, and cysts.
  • Treatment efficacy depends on acne severity and may involve topical agents (benzoyl peroxide, azelaic acid, retinoids, antibiotics) or systemic medications.
  • Isotretinoin offers a potential for permanent healing in severe cases.

Conclusions:

  • Patient-physician communication is crucial for successful acne management.
  • Comprehensive treatment plans, tailored to individual needs, are essential for managing acne vulgaris.
  • Achieving significant results from acne treatments typically requires approximately six months of consistent therapy.