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Impact of Intercellular Adhesion Molecule-1 Genetic Polymorphisms on Coronary Artery Disease Susceptibility in

Chi-Hung Chou1, Kwo-Chang Ueng2, Yu-Fan Liu3

  • 11. Institute of Medicine, Chung Shan Medical University,110, Section 1, Chien-Kuo North Road, Taichung, 40201, Taiwan ; 2. Division of Cardiology, Department of Internal Medicine, Yuan-Sheng Hospital and Changhua Christian Hospital, Yuanlin Branch, Yuanlin, Taiwan.

International Journal of Medical Sciences
|June 17, 2015
PubMed

Insights

The study found that the ICAM-1 gene variant rs281432 is linked to coronary artery disease (CAD) risk in Taiwanese individuals. Specifically, the rs281432 CC/CG genotype increases CAD risk, while the GG genotype appears protective.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Biology
  • Epidemiology

Background:

  • Coronary artery disease (CAD) pathogenesis involves chronic inflammation and atherosclerosis.
  • Intercellular adhesion molecule-1 (ICAM-1) plays a role in inflammation and atherosclerosis development.
  • Limited research exists on the association between ICAM-1 genetic polymorphisms and CAD in Taiwanese populations.

Purpose of the Study:

  • To investigate the association between ICAM-1 single nucleotide polymorphisms (SNPs), specifically rs5491, rs5498, rs281432, and rs3093030, and the risk of developing CAD in Taiwanese subjects.
  • To analyze the relationships among ICAM-1 SNPs, haplotypes, demographic characteristics, and CAD.

Main Methods:

  • Recruitment of 525 Taiwanese subjects undergoing elective coronary angiography.
  • Determination of four ICAM-1 SNPs (rs5491, rs5498, rs281432, rs3093030) using real-time polymerase chain reaction and genotyping.
  • Multivariate analysis to assess the relationships between ICAM-1 SNPs, clinical factors, and CAD.

Main Results:

  • The ICAM-1 SNP rs281432 (C8823G) was identified as the sole SNP significantly affecting CAD development.
  • Multivariate analysis indicated that the rs281432 CC/CG genotype (OR: 2.56, 95% CI: 1.19-5.56, p=0.016) is associated with increased CAD risk.
  • Other significant risk factors included male gender, aspirin use, hypertension, elevated cardiac troponin I, and severe angina.

Conclusions:

  • The ICAM-1 SNP rs281432 is an independent predictor for CAD development in the Taiwanese population.
  • The homozygotic mutant GG genotype of ICAM-1 SNP rs281432 may confer reduced susceptibility to CAD.

Keywords:
Coronary artery diseaseTaiwanese.genetic polymorphismhaplotypeintercellular adhesion molecule-1rs281432

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