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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Updated: Apr 10, 2026

A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
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Cell-based therapy for kidney disease.

Hyun Chul Chung1, In Kap Ko2, Anthony Atala2

  • 1Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA. ; Department of Urology, Yonsei University Wonju College of Medicine, Wonju, Korea.

Korean Journal of Urology
|June 17, 2015
PubMed
Summary
This summary is machine-generated.

Cell therapy offers a promising approach to treat kidney diseases, potentially restoring renal structure and function. This review explores various cell sources and recent advancements in cell-based treatments for renal pathologies.

Keywords:
Acute kidney injuryCell- and tissue-based therapyChronic kidney failureClinical trialEvaluation studies

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Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Biotechnology

Background:

  • Global prevalence of kidney disease is rising, leading to end-stage renal failure.
  • Current treatments like dialysis cannot fully restore kidney function.
  • Cell-based therapy presents a potential therapeutic strategy for renal pathologies.

Purpose of the Study:

  • To review cell therapy approaches for treating kidney diseases.
  • To discuss various cell sources utilized in regenerative nephrology.
  • To highlight recent advances in preclinical and clinical cell therapy studies for renal conditions.

Main Methods:

  • Literature review of preclinical and clinical studies on cell therapy for kidney diseases.
  • Analysis of different cell types and their therapeutic potential.
  • Synthesis of recent advancements and outcomes in the field.

Main Results:

  • Cell therapy has shown promising outcomes in restoring renal structure and function.
  • Various cell sources are being investigated for their efficacy.
  • Significant progress has been made in both preclinical and clinical research.

Conclusions:

  • Cell-based therapy is a viable and evolving therapeutic option for kidney diseases.
  • Further research and clinical trials are crucial to optimize treatment strategies.
  • Regenerative medicine holds significant promise for managing renal pathologies.