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Assaying Protein Kinase Activity with Radiolabeled ATP

Assaying Protein Kinase Activity with Radiolabeled ATP

Published on: May 26, 2017

DYRK protein kinases.

Ulf Soppa¹, Walter Becker¹

¹Institute of Pharmacology and Toxicology, Medical Faculty of RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany.

Current Biology : CB

|June 17, 2015

Summary

Soppa and Becker discuss the DYRK family of dual specificity protein kinases. These kinases have diverse functions and are linked to various genetic diseases.

Area of Science:

Biochemistry
Molecular Biology
Genetics

Background:

The DYRK (Dual-specificity Tyrosine phosphorylation-Regulated Kinase) family comprises protein kinases with crucial roles in cellular processes.
Dysregulation of DYRK kinase activity is implicated in the pathogenesis of several genetic disorders.

Purpose of the Study:

To introduce the DYRK family of protein kinases.
To summarize their diverse biological functions.
To highlight their association with human genetic diseases.

Main Methods:

Literature review and synthesis of existing research on DYRK kinases.
Analysis of functional roles and disease associations.

Main Results:

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Last Updated: Apr 10, 2026

Assaying Protein Kinase Activity with Radiolabeled ATP

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Published on: May 26, 2017

Assaying the Kinase Activity of LRRK2 in vitro

Assaying the Kinase Activity of LRRK2 in vitro

Published on: January 18, 2012

Identification of Kinase-substrate Pairs Using High Throughput Screening

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

The DYRK family includes several key kinases involved in cell proliferation, differentiation, and signaling.

Specific DYRK kinases are linked to conditions such as Down syndrome and certain cancers.

Conclusions:

The DYRK family represents an important target for understanding and potentially treating genetic diseases.
Further research into DYRK kinase biology is warranted.