A robust enzymeless glucose sensor based on CuO nanoseed modified electrodes.

Area of Science:

• Materials Science
• Electrochemistry
• Biomedical Engineering

Background:

• Glucose sensors are crucial for diabetes management.
• Existing glucose sensors often rely on enzymes, which can be unstable.
• Development of stable, enzymeless glucose sensors is highly desirable.

Purpose of the Study:

• To fabricate a robust enzymeless glucose sensor using copper oxide nanoseeds (CNSs).
• To evaluate the electrocatalytic performance of the CNS-based sensor.
• To assess the sensor's applicability in real biological samples.

Main Methods:

• Synthesis of CuO nanoseeds (CNSs) at low temperature.
• Fabrication of the glucose sensor using CNSs.
• Electrochemical characterization of the sensor's performance.
• Determination of glucose concentration in mice whole blood and serum.

Main Results:

• The fabricated sensor demonstrated robust and excellent electrocatalytic ability.
• The sensor exhibited a wide linear range for glucose detection.
• Successful determination of glucose concentration in freshly drawn mice whole blood and serum samples was achieved.

Conclusions:

• Low-temperature synthesized CuO nanoseeds provide a promising platform for robust enzymeless glucose sensing.
• The developed sensor shows potential for practical applications in biological fluid analysis.
• This work contributes to the advancement of electrochemical biosensors.