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Management of multicentric paragangliomas: Review of 24 patients with 60 tumors
Ricardo J González-Orús Álvarez-Morujo1, Miguel Ángel Arístegui Ruiz1, Daniel Poletti Serafini1
1Ear, Nose, and Throat Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Background:
The purpose of this study was to reflect our experience in the management of multicentric head and neck paragangliomas, including genetic study and counseling, diagnostic tools, types of treatment, and the need for monitoring.
Methods:
A retrospective review of 24 patients with multicentric paraganglioma, including a total of 60 paragangliomas: 37 carotid body tumors, 13 jugulotympanic paragangliomas, and 10 vagal paragangliomas.
Results:
A total of 26 surgical procedures were performed, including the resection of 36 paragangliomas. Four tumors were pending surgery at the time of this review. Radiotherapy was administered in 7 patients with 9 tumors. A "wait-and-scan" policy with periodic MRI imaging tests was instituted for 9 patients with 12 paragangliomas.
Conclusion:
The knowledge of the different modalities of management is especially relevant in patients with multicentric paragangliomas. In every case, benefits and potential risks of all treatment options may be taken into consideration for every individual patient.
