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Elastic sealants for surgical applications.

Nasim Annabi1, Kan Yue2, Ali Tamayol2

  • 1Department of Chemical Engineering, Northeastern University, Boston, MA 02115-5000, USA; Biomaterials Innovations Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|June 17, 2015
PubMed
Summary

This review covers advances in elastic surgical sealants, which aim to replace sutures and staples for preventing leaks. Current limitations are discussed to guide the development of improved bioadhesives for clinical use.

Keywords:
AdhesionElasticityHydrogelSurgical applicationsSurgical sealantsTissue adhesives

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Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • Adhesive Technology

Background:

  • Surgical sealants offer an alternative to traditional sutures and staples for preventing air and liquid leakage.
  • Key factors for sealant success include physical properties and adhesion strength without restricting tissue movement.
  • Elasticity is crucial for sealants in applications requiring tissue flexibility.

Purpose of the Study:

  • To critically review advancements in elastic surgical sealants derived from synthetic and natural materials.
  • To identify and discuss the shortcomings and limitations of currently available elastic sealants.
  • To provide insights for developing novel bioadhesives with enhanced functionality for surgical applications.

Main Methods:

  • Literature review of synthetic and natural material-based elastic sealants.
  • Analysis of sealant properties, including adhesion strength and elasticity.
  • Identification of critical applications and limitations of existing surgical sealants.

Main Results:

  • Advances in elastic sealant development from diverse materials have been reviewed.
  • Shortcomings and limitations of current elastic surgical sealants are identified.
  • Specific applications where sealant elasticity is critical have been highlighted.

Conclusions:

  • Elastic surgical sealants show promise for replacing sutures and staples.
  • Further development is needed to overcome limitations in current bioadhesives.
  • This review guides the creation of next-generation surgical sealants with improved functionality.