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Related Experiment Video

Updated: Apr 10, 2026

Metal-silicate Partitioning at High Pressure and Temperature: Experimental Methods and a Protocol to Suppress Highly Siderophile Element Inclusions
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Cylindruria.

Alberta Caleffi, Giuseppe Lippi

    Clinical Chemistry and Laboratory Medicine
    |June 17, 2015
    PubMed
    Summary

    Urine sediment analysis, particularly identifying urinary casts, is vital for diagnosing kidney disorders. Proper classification of these Tamm-Horsfall glycoprotein structures aids in accurate and timely medical diagnosis.

    Area of Science:

    • Nephrology
    • Clinical Urinalysis
    • Biochemistry

    Background:

    • Urinary casts are cylindrical structures formed in renal tubules from Tamm-Horsfall glycoprotein (THG).
    • Their formation is influenced by urine osmolality and pH, occurring in both physiological and pathological states.
    • Casts are present in healthy individuals and various renal and non-renal diseases.

    Purpose of the Study:

    • To highlight the significance of morphological analysis of urinary casts in urinalysis.
    • To emphasize the role of casts in the diagnosis of renal disorders.
    • To underscore the importance of proper training for laboratory professionals in cast identification.

    Main Methods:

    • Morphological classification of urinary casts.
    • Analysis of factors influencing cast formation.

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  • Review of clinical significance in urinalysis.

    • Main Results:

    • Casts are diverse, classified by morphology (hyaline, granular, waxy, fatty, cellular, etc.).
    • Presence of casts is indicative of various physiological and pathological conditions.
    • Accurate identification is critical for diagnosing renal conditions.

    Conclusions:

    • Morphological analysis of urinary casts is a cornerstone of urinalysis.
    • Proper identification and classification of casts are essential for accurate renal disorder diagnosis.
    • Training laboratory professionals is crucial for effective clinical urinalysis.