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High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
Published on: July 17, 2014
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Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013
Emerging Infectious Diseases
|June 17, 2015
Abstract:
Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.
Keywords:
Plasmodium falciparumUgandaartesunatechildkelch 13 propeller domainmalariaparasitesresistancesingle nucleotide polymorphismMore Related Videos
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