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Independent associations between resistin and left ventricular mass and myocardial dysfunction in a community sample

Glenda Norman1, Gavin R Norton1, Carlos D Libhaber2

  • 1Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

International Journal of Cardiology
|June 17, 2015
PubMed

Insights

Resistin, a hormone, is linked to increased left ventricular mass and impaired systolic function in heart failure, independent of other factors. These findings clarify resistin's role in cardiac remodeling and dysfunction.

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Biomarkers

Background:

  • The adipokine resistin's role in heart failure is not fully understood.
  • Mechanisms linking resistin to left ventricular mass (LVM) and function require clarification.

Purpose of the Study:

  • To investigate the association between circulating resistin concentrations and LVM, inappropriate LVMI (LVMinappr), and left ventricular systolic and diastolic function.
  • To determine if these associations persist independently of confounders such as blood pressure, BMI, and insulin resistance.

Main Methods:

  • Cross-sectional study of 739 community participants.
  • Assessed circulating resistin concentrations via assays.
  • Evaluated LVM index (LVMI), LVMinappr, and LV systolic/diastolic function using echocardiography.
  • Statistical analysis included partial correlations, adjusting for multiple confounders.

Main Results:

  • Resistin concentrations were independently associated with LVMI, LVMinappr, and LV hypertrophy, independent of BP, BMI, and insulin resistance.
  • Associations remained significant after adjusting for C-reactive protein.
  • Resistin was the sole independent predictor of LV midwall fractional shortening, with enhanced relations at higher CRP levels.
  • No independent association was found between resistin and LV diastolic function indices.

Conclusions:

  • Resistin partially explains variations in LVM, hypertrophy, and myocardial systolic dysfunction.
  • These effects are independent of insulin resistance and general inflammatory processes.
  • Resistin emerges as a significant factor in cardiac remodeling and systolic dysfunction.
Abstract

Keywords:
Inappropriate left ventricular massMyocardial systolic functionObesityResistin

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