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Surface plasmon resonance: a label-free tool for cellular analysis.

Effat Zeidan1, Christopher L Kepley1, Christie Sayes1

  • 1University of North Carolina at Greensboro, Department of Nanoscience, 2907 E Lee Street, Greensboro, NC, 27401, USA.

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|June 18, 2015
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Summary

Surface Plasmon Resonance (SPR) offers sensitive, label-free analysis of biomolecular interactions. This review details SPR

Keywords:
bacterial adherence propertiesbiomolecular interactionscell sortingcellular detectioncellular morphology alterationscellular secretionslong-range surface plasmon resonancenanoscale cellular dynamicsoptical biosensorsingle-cell analysis

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Area of Science:

  • Biophysics
  • Biochemistry
  • Cell Biology

Background:

  • Surface Plasmon Resonance (SPR) is a widely adopted technique for analyzing molecular interactions.
  • SPR provides sensitive, specific, label-free, and real-time data.
  • It is a versatile tool applicable to various biomedical fields, including drug discovery and cell characterization.

Purpose of the Study:

  • To review the applications of SPR in monitoring cellular binding events.
  • To discuss how SPR tracks dynamic changes in cell adherence in response to stimuli.

Main Methods:

  • Literature review of studies utilizing SPR for cellular analysis.
  • Focus on SPR's capability to observe real-time cellular dynamics.

Main Results:

  • SPR effectively monitors biomolecular interactions with high sensitivity and specificity.
  • The technique allows for label-free, real-time assessment of cellular binding and morphological changes.
  • SPR's flexibility enables diverse applications in cell sorting, characterization, and drug discovery.

Conclusions:

  • SPR is a powerful, non-destructive tool for studying cellular binding dynamics and adherence.
  • Its real-time, label-free nature makes it invaluable for understanding cellular responses to external stimuli in biomedical research.