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Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
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An Update on the Pathogenesis of Osteochondrosis
K Olstad1, S Ekman2, C S Carlson3
1Faculty of Veterinary Medicine and Biosciences, Institute of Companion Animal Clinical Sciences, Norwegian University of Life Sciences, Oslo, Norway kristin.olstad@nmbu.no.
Veterinary Pathology
|June 18, 2015
Summary
Osteochondrosis, a disturbance in bone development, involves cartilage damage due to blood supply failure. Imaging techniques like CT and MRI help detect these lesions, which can sometimes resolve spontaneously.
Area of Science:
- Veterinary Pathology
- Developmental Biology
- Orthopedic Research
Background:
- Osteochondrosis is a focal disturbance in endochondral ossification.
- It can lead to cartilage fractures forming osteochondrosis dissecans (OCD) joint fragments.
- Vascular failure in epiphyseal growth cartilage causes ischemic chondronecrosis, a key feature in pigs and horses.
Purpose of the Study:
- To detail the pathogenesis and detection of osteochondrosis lesions.
- To explore spontaneous resolution mechanisms of osteochondrosis.
- To identify the causes of vascular failure and heritable predispositions in osteochondrosis.
Main Methods:
- Utilizing contrast-enhanced micro- and conventional computed tomography (CT) for ex vivo detection.
- Employing adiabatic T1ρ magnetic resonance imaging (MRI) for direct lesion visualization.
- Longitudinal studies in pigs using plain CT, combined with histological analysis.
Main Results:
- Osteochondrosis latens (early stage) and osteochondrosis manifesta (chronic stage) are detectable via CT and MRI.
- Spontaneous resolution of lesions was observed, occurring through bone infilling and tissue remodeling.
- Vascular failure appears linked to blood vessel incorporation during growth and can be induced by bacteremia.
Conclusions:
- Osteochondrosis involves complex vascular and ossification disturbances.
- CT and MRI are valuable tools for diagnosing and monitoring osteochondrosis.
- Further research is needed to elucidate the precise causes of vascular failure and genetic factors.
Keywords:
animalscausecomputed tomographyhumansmagnetic resonance imagingosteochondritis dissecansosteochondrosispathogenesisMore Related Videos
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