Related Experiment Video

Updated: Apr 10, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

17.3K

Precision medicine path for prostate cancer

    Cancer Discovery
    |June 18, 2015
    PubMed

    Insights

    Nearly 90% of metastatic castration-resistant prostate cancer patients harbor actionable genetic alterations. Over 60% of these genetic changes are targetable with existing or investigational drugs, paving the way for personalized prostate cancer therapies.

    Area of Science:

    • Oncology
    • Genetics
    • Pharmacology

    Background:

    • Metastatic castration-resistant prostate cancer (mCRPC) presents significant therapeutic challenges.
    • Identifying targetable genetic alterations is crucial for advancing mCRPC treatment.

    Discussion:

    • A recent study reveals that approximately 90% of mCRPC patients possess clinically actionable genetic alterations.
    • Among these, 65% exhibit genetic changes amenable to targeted therapy with existing or investigational drugs.

    Key Insights:

    • This high prevalence of targetable alterations underscores the potential for precision medicine in mCRPC.
    • Individualized treatment strategies can be developed based on specific genetic profiles.

    Outlook:

    • Further research into drug development targeting these specific alterations is warranted.
    • Implementation of genomic profiling in routine mCRPC care could optimize patient outcomes.

    More Related Videos

    Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking07:34

    Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

    Published on: November 17, 2023

    1.4K
    A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance05:19

    A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

    Published on: November 7, 2025

    1.1K

    Related Concept Videos

    Combination Therapies and Personalized Medicine02:50

    Combination Therapies and Personalized Medicine

    Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
    The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
    6.4K
    Targeted Cancer Therapies02:57

    Targeted Cancer Therapies

    The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
    There are several types of targeted therapies against...
    9.1K