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[Comparative study in clinical features and managements of aortic dissection between Chinese and Caucasians]

Shikai Shen1, Jian Zhang2, Yanshuo Han1

  • 1Department of Vascular Surgery, First Hospital of China Medical University, Shenyang 110001, China.

Zhonghua Yi Xue Za Zhi
|June 18, 2015
PubMed

Insights

Chinese patients with aortic dissection (AD) are younger and have more comorbidities than Caucasians. Early surgery in Chinese patients shows lower 30-day mortality, but more research is needed.

Area of Science:

  • Cardiovascular Surgery
  • Vascular Surgery
  • Public Health

Background:

  • Aortic dissection (AD) is a life-threatening condition with varying clinical presentations and outcomes across different ethnicities.
  • Understanding ethnic disparities in AD is crucial for developing targeted treatment strategies.

Purpose of the Study:

  • To compare the clinical characteristics, treatment modalities, and prognosis of aortic dissection (AD) between Chinese (Han) and Western (Caucasian) populations.
  • To identify potential ethnic-specific risk factors and outcomes in AD patients.

Main Methods:

  • A systematic review and meta-analysis of studies published between 1980 and 2014.
  • Databases searched include MEDLINE, Embase, CBM, and CNKI.
  • Statistical analysis was performed using STATA 12.0.

Main Results:

  • The study included a total of 15,177 patients (6,697 Caucasian, 8,500 Chinese Han).
  • Chinese Han patients were younger, had higher rates of smoking, coronary heart disease, hypertension, and diabetes compared to Caucasians.
  • Chinese patients presented more frequently with neurological and cardiac complications, while Caucasians showed more renal and peripheral vascular damage. Open surgery was more common in Chinese patients, and TEVAR was more frequent in domestic Chinese patients. The 30-day mortality for Stanford B AD was significantly lower in Chinese patients (2.4%) than in Caucasians (11.2%).

Conclusions:

  • The incidence of aortic dissection (AD) is increasing in younger Chinese patients with more underlying diseases.
  • Despite lower 30-day mortality and complication rates with early surgical intervention, further large-scale studies and long-term follow-up are necessary due to data limitations.
Abstract

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