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Mycosis in man due to Arthrinium phaeospermum var. indicum. First case report
Abstract:
Arthrinium phaeospermum var. indicum Kan & Sullia was repeatedly isolated from erythematous nodules of a patient. Scrapings of the experimental infection developed on rabbits revealed fungal filaments and few spores similar to those of A. phaeospermum var. indicum. The identity of the pathogen is discussed and it is being reported for the first time from human being. In vitro sensitivity of A. phaeospermum var. indicum to miconazole nitrate exhibited a minimum inhibition concentration of 6.25 micrograms/ml.
Insights
Arthrinium phaeospermum var. indicum, a fungus, was identified as the cause of a patient's skin condition. This marks the first reported human infection by this fungal variety, which showed sensitivity to miconazole nitrate.
Area of Science:
- Medical Mycology
- Dermatology
- Infectious Diseases
Background:
- Fungal infections can present with diverse clinical manifestations.
- Accurate identification of etiological agents is crucial for effective treatment.
Observation:
- Arthrinium phaeospermum var. indicum was consistently isolated from erythematous skin nodules.
- Experimental infections in rabbits showed fungal elements resembling the isolate.
Findings:
- Arthrinium phaeospermum var. indicum is reported as a novel human pathogen.
- The fungus demonstrated in vitro sensitivity to miconazole nitrate with a Minimum Inhibitory Concentration (MIC) of 6.25 µg/ml.
Implications:
- This study expands the known spectrum of human fungal pathogens.
- Miconazole nitrate may be a potential therapeutic option for infections caused by this fungus.