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Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
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Cerebral Ischemic Preconditioning: the Road So Far….
N Thushara Vijayakumar1, Amit Sangwan1, Bhargy Sharma1
1School of Biotechnology, DBT-Centre for Bioinformatics, National Institute of Technology Calicut, Calicut, 673601, India.
Molecular Neurobiology
|June 18, 2015
Summary
Cerebral preconditioning offers temporary brain protection against stroke by activating protective mechanisms. Research explores various stimuli and pathways to translate these findings into clinical treatments for ischemic stroke.
Area of Science:
- Neuroscience
- Cerebrovascular Research
- Molecular Biology
Background:
- Cerebral preconditioning involves the brain's adaptation to mild stressors, conferring temporary resistance to lethal ischemia.
- This phenomenon, well-studied in cardiac models, is increasingly recognized in the brain, offering potential neuroprotection.
- Ischemic stroke remains a major cause of death and disability worldwide, highlighting the need for effective treatments.
Purpose of the Study:
- To review current advancements in cerebral preconditioning research.
- To examine the molecular mechanisms underlying ischemic tolerance in the brain.
- To evaluate the clinical relevance and potential of various preconditioning strategies for stroke management.
Main Methods:
- Review of existing in vivo and in vitro studies on cerebral preconditioning.
- Analysis of molecular signaling pathways and biomolecules involved in inducing ischemic tolerance.
- Evaluation of different preconditioning stimuli, including remote ischemic and pharmacological approaches.
Main Results:
- Preconditioning activates diverse molecular machinery, leading to genomic reprogramming and a transient protective phenotype (ischemic tolerance).
- Various stimuli, such as hypoxia and anesthetics, can induce preconditioning by activating specific cellular pathways.
- Remote ischemic preconditioning and pharmacological preconditioning show promise for clinical application in stroke.
Conclusions:
- Cerebral preconditioning represents a promising avenue for neuroprotection against ischemic stroke.
- Translating experimental findings into clinical practice faces challenges but holds significant therapeutic potential.
- Further investigation into preconditioning agents is crucial for developing effective stroke management strategies.
Keywords:
Cerebral ischemiaEpigeneticsGenomic reprogrammingIschemic toleranceNeuroprotectionPreconditioning
