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[Impact of left atrium size on left atrial thrombus in patients with non-valvular persistent atrial fibrillation]

Ribo Tang1, Jianzeng Dong1, Meisheng Shang1

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Zhonghua Yi Xue Za Zhi
|June 18, 2015
PubMed

Insights

Left atrial enlargement is a significant independent risk factor for left atrial thrombus in patients with non-valvular persistent atrial fibrillation. A left atrial diameter of 42.5 mm or greater increases the risk of thrombus formation.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Clinical Research

Background:

  • Atrial fibrillation (AF) increases stroke risk, often due to left atrial (LA) thrombus.
  • Predicting LA thrombus is crucial for stroke prevention in non-valvular persistent AF patients.

Purpose of the Study:

  • To investigate the relationship between left atrium size and the presence of LA thrombus.
  • To determine if LA size is an independent predictor of LA thrombus in non-valvular persistent AF.

Main Methods:

  • Prospective study of 367 non-valvular persistent AF patients undergoing transesophageal echocardiography.
  • Analysis included LA diameter, left ventricular dimensions, ejection fraction, and CHA2DS2Vasc score.
  • Logistic regression and ROC curve analysis were used to identify predictors of LA thrombus.

Main Results:

  • LA thrombus was present in 8.7% of patients.
  • Patients with LA thrombus had significantly larger LA diameter and reduced left ventricular ejection fraction.
  • LA diameter ≥ 42.5 mm was identified as an independent risk factor for LA thrombus (OR 2.77, P=0.021).

Conclusions:

  • Left atrial enlargement is a significant independent risk factor for LA thrombus in non-valvular persistent AF.
  • LA diameter ≥ 42.5 mm effectively predicts LA thrombus formation.
  • These findings aid in risk stratification and stroke prevention strategies.
Abstract

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