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Novel (pyrazolyl)benzenesulfonamides with a nitric oxide-releasing moiety as selective cyclooxygenase-2 inhibitors

Nicole Bechmann1, Torsten Kniess2, Martin Köckerling3

  • 1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department Radiopharmaceutical and Chemical Biology, Bautzner Landstrasse 400, 01328 Dresden, Germany; Technische Universität Dresden, Department of Chemistry and Food Chemistry, 01069 Dresden, Germany.

Bioorganic & Medicinal Chemistry Letters
|June 18, 2015
PubMed

Keywords:
Anti-inflammatory therapyCardiovascular side effectsCelecoxibDirect/indirect NO couplingGriess assayOrganic nitrate

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