Related Experiment Video

Updated: Apr 10, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.7K

[Depression comorbid to ischemic heart disease: a psychometric and molecular-genetic study]

V E Golimbet1, B A Volel2, G I Korovaitseva1

  • 1Mental Health Research Center, Moscow.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|June 18, 2015
PubMed

Insights

Depression linked to ischemic heart disease (IHD) shows distinct apathy without anxiety or guilt. This psychometric profile correlates with specific genetic markers, including serotonin transporter and receptor genes.

Area of Science:

  • Cardiology
  • Psychiatry
  • Genetics

Background:

  • Depression is a common comorbidity in patients with ischemic heart disease (IHD).
  • Differentiating depression etiologies in IHD patients is crucial for targeted treatment.
  • Psychogenic factors can also precipitate depression in individuals with IHD.

Purpose of the Study:

  • To compare the psychometric profiles of depression associated with IHD versus depression caused by other psychogenic factors in IHD patients.
  • To identify the molecular-genetic characteristics associated with depression specifically linked to IHD.

Main Methods:

  • A cohort of 135 patients with depression comorbid to IHD was analyzed.
  • Patients were divided into two groups: depression associated with IHD (n=71) and depression due to other psychogenic factors (n=64).
  • Depressive symptoms were assessed using the HAMD-21 scale.

Main Results:

  • Patients with IHD-associated depression exhibited a unique psychometric profile characterized by significant apathy.
  • This apathy was not accompanied by pronounced hypothymia, guilt, or anxiety, distinguishing them from the other group.
  • A specific molecular-genetic correlate was identified, involving alleles S (5-HTTLPR) and G (A-1438G), and genotype ValVal (Val66Met).

Conclusions:

  • Depression in the context of IHD presents a distinct psychometric phenotype, primarily marked by apathy.
  • This specific depressive profile in IHD patients is associated with a unique combination of genetic variations in serotonin transporter, serotonin receptor type 2A, and brain-derived neurotrophic factor genes.
Abstract

More Related Videos

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

11.0K
Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

730

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
4.0K
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
461
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
871
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
706
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.0K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.1K