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[Psychoneuroimmunology and multiple sclerosis].

M V Melnikov¹, М V Pashchekov², A N Boyко³

¹Pirogov Russian National Research Medical University, Moscow.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova

|June 18, 2015

Summary

This review explores how mental, nervous, and immune systems interact in multiple sclerosis. It examines how stress affects disease progression and discusses potential underlying mechanisms.

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Area of Science:

Neuroimmunology
Psychoneuroimmunology

Context:

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
Understanding the interplay between psychological factors and immune responses in MS is crucial for disease management.

Purpose:

To review the complex interactions between the mental, nervous, and immune systems in the context of multiple sclerosis.
To elucidate the impact of psycho-emotional stress on the development and progression of multiple sclerosis.
To explore the potential biological mechanisms underlying these mind-body interactions in MS.

Summary:

The review highlights bidirectional communication pathways between the brain, nervous system, and immune cells relevant to multiple sclerosis pathogenesis.
Psycho-emotional stress emerges as a significant factor influencing MS disease activity, potentially exacerbating neuroinflammation and demyelination.
Proposed mechanisms involve the modulation of immune cell function, cytokine profiles, and neuroendocrine pathways by stress.

Impact:

Provides a comprehensive overview of the psychoneuroimmunological aspects of multiple sclerosis.
Offers insights into novel therapeutic targets for managing MS by considering mental and emotional health.
Facilitates a better understanding of how stress impacts the nervous and immune systems in autoimmune neurological disorders.