[Quantitative evaluation of aortic regurgitation by general imaging three-dimensional quantification]

Area of Science:

• Cardiovascular Imaging
• Echocardiography
• Medical Device Technology

Background:

• Aortic regurgitation (AR) is a significant valvular heart disease.
• Accurate quantification of AR volume (AR-Vol) is crucial for clinical management.
• Existing methods for AR-Vol measurement have limitations.

Purpose of the Study:

• To evaluate the feasibility and clinical utility of the GI3DQ method for direct AR-Vol measurement.
• To compare AR-Vol measurements obtained by the GI3DQ method against the established PISA method.

Main Methods:

• One hundred and two patients with AR were enrolled.
• Patients were categorized into eccentric (40) and central (62) AR groups.
• AR-Vol was measured directly using the GI3DQ method and compared with PISA method calculations.

Main Results:

• In central AR, GI3DQ yielded AR-Vol of 34±13 ml vs. PISA's 33±13 ml (P=0.202).
• In eccentric AR, GI3DQ yielded AR-Vol of 44±11 ml vs. PISA's 48±10 ml (P<0.01).
• High correlation (r=0.913) and consistency were observed for central AR between methods; lower correlation (r=0.835) for eccentric AR.

Conclusions:

• The GI3DQ method is a feasible and accurate tool for measuring AR-Vol in central aortic regurgitation.
• GI3DQ demonstrates potential for routine clinical application in assessing central AR.
• Further validation may be needed for eccentric aortic regurgitation assessment.