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Analysis of mRNA Nuclear Export Kinetics in Mammalian Cells by Microinjection
11:32

Analysis of mRNA Nuclear Export Kinetics in Mammalian Cells by Microinjection

Published on: December 4, 2010

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Control of mammalian gene expression by selective mRNA export

Vihandha O Wickramasinghe1, Ronald A Laskey2

  • 1Medical Research Centre (MRC) Cancer Unit, Hutchison/MRC Research Centre, Box 197, Biomedical Campus, Cambridge CB2 0XZ, UK.

Nature Reviews. Molecular Cell Biology
|June 18, 2015
PubMed

Insights

Nuclear export of messenger RNAs (mRNAs) links gene transcription to protein translation. Recent studies reveal selective mRNA export in mammals regulates key cellular functions, impacting gene expression and the transcriptome.

Area of Science:

  • Molecular Biology
  • Gene Expression Regulation
  • Cellular Biology

Background:

  • Nuclear export of messenger RNAs (mRNAs) is essential for gene expression, connecting nuclear transcription to cytoplasmic translation.
  • Key components like the TREX and TREX-2 transcription-export complexes are known, but the selectivity of this process is under investigation.

Purpose of the Study:

  • To explore the selective nature of mammalian mRNA export.
  • To understand the role of selective mRNA export in regulating critical biological processes.

Main Methods:

  • This study reviews recent findings on mRNA export mechanisms.
  • Analysis of literature focusing on selective export pathways and their regulatory roles.

Main Results:

  • Mammalian mRNA export is not a uniform process; it can be selective.
  • Selective mRNA export influences vital cellular activities including DNA repair, pluripotency maintenance, and cell survival.

Conclusions:

  • mRNA export represents an underappreciated mechanism for controlling gene expression.
  • Selective mRNA export plays a significant role in regulating the mammalian transcriptome and cellular functions.

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