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The effect of methotrexate on the development of synapses in the neonatal rat hippocampus
H Igarashi1, K Inomata, A Tateno
1Second Department of Anatomy, Toho University School of Medicine, Tokyo, Japan.
Neuropediatrics
|November 1, 1989
Abstract:
The effects of postnatal methotrexate (MTX) exposure on the development of synapses in the developing rat hippocampus were examined. The density of E-PTA-stained synaptic junctions per unit area was significantly reduced by MTX exposure either during day 1-5 or 6-10 post partum. It was suggested that administering MTX during the critical period affected the development of synapses in the developing rat brain.