Related Experiment Video

Updated: Apr 10, 2026

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
09:48

Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance

Published on: February 17, 2023

3.7K

TLR3 and its roles in the pathogenesis of type 2 diabetes

Z Sepehri1, Z Kiani2, F Javadian3

  • 1Zabol University of Medical Sciences Department of Internal Medicine Zabol Iran.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|June 18, 2015
PubMed

Insights

Toll-like receptor 3 (TLR3) plays a critical role in the immune system and may contribute to type 2 diabetes (T2D) development. Understanding TLR3

Area of Science:

  • Immunology
  • Endocrinology
  • Molecular Biology

Background:

  • Type 2 diabetes (T2D) is a widespread non-infectious disease with severe complications like nephropathy and retinopathy.
  • The precise mechanisms and signaling molecules driving T2D pathogenesis and its complications remain largely unknown.
  • Genetic and immunological factors are suspected to influence T2D susceptibility.

Purpose of the Study:

  • To review current research on the role of Toll-like receptor 3 (TLR3) in the progression and pathogenesis of Type 2 Diabetes.
  • To explore the involvement of TLR3 signaling pathways in immune-regulated diseases like T2D.

Main Methods:

  • Literature review of recent scientific data.
  • Analysis of TLR3's function as an intracellular ligand.
  • Examination of the TRIF signaling pathway activation by TLR3.

Main Results:

  • Toll-like receptors (TLRs) are implicated in cellular proliferation and apoptosis, suggesting complex roles in T2D.
  • TLR3, an intracellular ligand, activates signaling via the TRIF pathway.
  • Altered TLR3 expression or function may inappropriately activate immune responses linked to T2D.

Conclusions:

  • TLR3 and its signaling pathways are significant candidates for investigation in T2D pathogenesis.
  • Dysregulation of TLR3 may contribute to the immune-mediated aspects of Type 2 Diabetes.
  • Further research into TLR3's role is crucial for understanding and potentially treating T2D.

More Related Videos

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

10.4K
An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

4.4K

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.5K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.8K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
15.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.2K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.4K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.9K