Related Experiment Video

Updated: Apr 10, 2026

Particle Agglutination Method for Poliovirus Identification
07:06

Particle Agglutination Method for Poliovirus Identification

Published on: April 20, 2011

16.0K

Aichi Virus Positivity in HIV-1 Seropositive Children Hospitalized with Diarrheal Disease

Silvana Augusta Rodrigues Portes, Eduardo de Mello Volotao, Tatiana Lundgren Rose

  • 1Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Laboratory of Comparative and Environmental Virology, Pav. Helio & Peggy Pereira, Av. Brazil 4.365 - Manguinhos - 21040-360 - Rio de Janeiro - RJ - Brazil. sil@ioc.fiocruz.br.

Current HIV Research
|June 18, 2015
PubMed

Insights

Aichi virus (AiV) infection is more common in hospitalized children with diarrhea and HIV-1, suggesting it may be an opportunistic pathogen in children with AIDS and diarrhea.

Area of Science:

  • Virology
  • Infectious Diseases
  • Pediatrics

Background:

  • Aichi viruses (AiV) are associated with diarrheal diseases (DD).
  • Understanding AiV prevalence in vulnerable pediatric populations is crucial.

Purpose of the Study:

  • To determine Aichi virus infection rates in hospitalized children with diarrhea.
  • To compare infection rates between HIV-1 seropositive and seronegative children.
  • To perform phylogenetic analysis of detected AiV strains.

Main Methods:

  • Nested RT-PCR was used to detect AiV in stool samples.
  • Co-infections with other enteric viruses were assessed.
  • Partial genome sequencing and phylogenetic analysis were conducted on AiV isolates.

Main Results:

  • AiV was detected in 7.32% of HIV-1 seropositive children and 0.8% of HIV-1 seronegative children with DD (p = 0.019).
  • Phylogenetic analysis identified AiV genotypes A and B.
  • Genotype A strains clustered into three distinct genetic groups.

Conclusions:

  • Aichi virus may act as an opportunistic pathogen in children with Acquired Immunodeficiency Syndrome (AIDS) and diarrhea.
  • HIV-1 infection is a significant risk factor for AiV detection in children with DD.
  • Further research into AiV pathogenesis in immunocompromised children is warranted.

More Related Videos

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions08:01

Author Spotlight: Investigating Viral Disruption of Intestinal Epithelial Signaling – Research Insights and Future Directions

Published on: January 19, 2024

2.1K
Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique09:37

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

2.3K

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
50
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
42
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
42
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
133
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
6.1K
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
55