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Updated: Apr 10, 2026

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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Published on: September 15, 2023

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FOXM1 and its Oncogenic Signaling in Gastric Cancer

Hanying Wang, Chen Huang1

  • 1Department of General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital, 100 Haining Road, Shanghai 200080, P.R. China. richard-hc@hotmail.com.

Recent Patents on Anti-Cancer Drug Discovery
|June 18, 2015
PubMed

Insights

The transcription factor Forkhead box M1 (FOXM1) is overexpressed in numerous cancers and drives tumor growth and metastasis. This review details FOXM1

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The transcription factor Forkhead box M1 (FOXM1) is frequently overexpressed in various human cancers.
  • FOXM1 plays a critical role in cancer cell initiation, progression, metastasis, and drug resistance.

Purpose of the Study:

  • To review the specific effects of FOXM1 on gastric cancer.
  • To discuss the function and regulation of FOXM1 in gastric tumorigenesis and chemotherapy.
  • To summarize recent patents related to FOXM1 in cancer therapy.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of recent patents concerning FOXM1 in tumor therapy.

Main Results:

  • FOXM1 overexpression is linked to poor prognosis in multiple cancers.
  • FOXM1 regulates key genes involved in cell cycle progression and DNA repair.
  • FOXM1 influences response to various chemotherapeutic agents.

Conclusions:

  • FOXM1 is a significant oncogenic driver in gastric cancer.
  • Targeting FOXM1 presents a promising therapeutic strategy for gastric cancer treatment.
  • Further research and patent development are crucial for FOXM1-targeted therapies.

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