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Updated: Apr 10, 2026

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
Functional roles of connexins and pannexins in the kidney
Ahmed B Abed1, Panagiotis Kavvadas, Christos E Chadjichristos
1INSERM UMR-S1155, Batiment Recherche, Tenon Hospital, 4 rue de la Chine, 75020, Paris, France.
Abstract:
Kidneys are highly complex organs, playing a crucial role in human physiopathology, as they are implicated in vital processes, such as fluid filtration and vasomotor tone regulation. There is growing evidence that gap junctions are major determinants of renal physiopathology. It has been demonstrated that their expression or channel activity may vary depending on physiological and pathological situations within distinct renal compartments. While some studies have focused on the role of connexins in renal physiology, our knowledge regarding the functional relevance of pannexins is still very limited. In this paper, we provide an overview of the involvement of connexins, pannexins and their channels in various physiological processes related to different renal compartments.
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