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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Related Experiment Video

Updated: Apr 10, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

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Infundibulocystic Squamous Cell Carcinoma.

So Min Kim1, Hyeree Kim1, Hei Sung Kim1

  • 1Department of Dermatology, Incheon St. Mary's Hospital, School of Medicine, The Catholic University of Korea, Incheon, Korea.

Annals of Dermatology
|June 18, 2015
PubMed
Summary

Infundibulocystic squamous cell carcinoma, a rare hair follicle tumor, is detailed in this case report. The study focuses on a specific instance of this infiltrative cancer found on a patient's ear.

Keywords:
Squamous cell carcinoma

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Area of Science:

  • Dermatopathology
  • Oncology
  • Surgical Pathology

Background:

  • Infundibulocystic squamous cell carcinoma (ICSC) is a rare subset of squamous cell carcinoma originating from the hair follicle's infundibulum.
  • Initially described in 2008, it was redefined by Misago et al. in 2011 to encompass only the infiltrative form due to distinct clinical and histological features.

Observation:

  • This report presents a case of ICSC in a 72-year-old male patient.
  • The patient exhibited a mass on the left helix of the ear, a common site for skin neoplasms.

Findings:

  • The case highlights the characteristic infiltrative nature of ICSC.
  • Diagnostic confirmation relies on detailed histological examination to differentiate it from other squamous cell carcinoma variants.

Implications:

  • This case contributes to the understanding of ICSC's clinical presentation and histological spectrum.
  • Accurate diagnosis is crucial for appropriate patient management and treatment planning of this rare malignancy.