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Gray Matter Volume Changes in the Apathetic Elderly.

Hongjie Yan1, Keiichi Onoda1, Shuhei Yamaguchi1

  • 1Department of Neurology, Faculty of Medicine, Shimane University , Izumo , Japan.

Frontiers in Human Neuroscience
|June 18, 2015
PubMed
Summary
This summary is machine-generated.

Apathy in healthy older adults is linked to structural brain changes in the prefrontal-basal-ganglia circuit. These gray matter alterations suggest a distinct neuroanatomical basis for apathy, separate from depression.

Keywords:
apathybasal gangliafrontal lobegray matter volumeprecentral gyrusvoxel-based morphometry

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Area of Science:

  • Neuroscience
  • Gerontology
  • Brain Imaging

Background:

  • Apathy is a common neuropsychiatric symptom in aging.
  • The neurobiological underpinnings of apathy in healthy elderly individuals remain unclear.
  • Investigating structural brain changes associated with apathy is crucial for understanding its etiology.

Purpose of the Study:

  • To test the hypothesis that apathy in healthy aged participants is associated with the prefrontal-basal-ganglia circuit.
  • To identify specific gray matter structural changes linked to apathy in this population.
  • To differentiate the neuroanatomical basis of apathy from depression.

Main Methods:

  • Voxel-based morphometry (VBM) analysis of structural MRI scans.
  • Comparison of gray matter volumes between healthy aged participants with and without apathy (n=18 each).
  • Inclusion of depression scores as a covariate in regression models.

Main Results:

  • Apathy group showed reduced gray matter volume in the right putamen.
  • Increased gray matter volumes were observed in the bilateral inferior frontal gyri and left inferior occipital gyrus in the apathy group.
  • After accounting for depression, apathetic participants exhibited decreased gray matter volume in the right precentral gyrus.

Conclusions:

  • Apathy in healthy elderly individuals is associated with gray matter volume alterations within the prefrontal-basal-ganglia network.
  • These findings suggest a distinct neuroanatomical basis for apathy that is separable from depression.
  • Structural MRI and VBM are valuable tools for exploring the neurobiology of apathy in aging populations.