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Treatment of Recurrent Hepatitis C Genotype-4 Post-Liver Transplantation with Sofosbuvir plus Simeprevir

Mustafa Ascha1, Mona Ascha1, N N Zein1

  • 1Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio, United States.

International Journal of Organ Transplantation Medicine
|June 18, 2015
PubMed

Insights

Hepatitis C virus (HCV) recurrence after liver transplant is common. Simeprevir (SIM) and sofosbuvir (SOF) effectively cleared HCV genotype-4 in three transplant patients, showing promise for this challenging group.

Area of Science:

  • Hepatology
  • Virology
  • Transplantation Medicine

Background:

  • Hepatitis C virus (HCV) infection is a primary reason for liver transplantation globally.
  • HCV recurrence post-orthotopic liver transplantation (OLT) is nearly universal.
  • Limited data exists on treating HCV genotype-4, prevalent in North Africa and the Middle East, after OLT.

Observation:

  • Three patients with HCV genotype-4 recurrence post-OLT were treated.
  • All patients were treatment-naive and received simeprevir (SIM) and sofosbuvir (SOF) for 12-24 weeks.
  • This case series observed the outcomes of SIM+SOF combination therapy.

Findings:

  • SIM+SOF treatment demonstrated good tolerability in the observed patients.
  • Viral clearance was achieved in all three HCV genotype-4 post-OLT patients.
  • The combination therapy proved effective for managing recurrent HCV genotype-4.

Implications:

  • Simeprevir and sofosbuvir show potential as an effective treatment for HCV genotype-4 recurrence post-OLT.
  • Further research is warranted to confirm these findings in larger cohorts.
  • This study highlights a potential therapeutic option for a specific patient population with limited treatment data.

Keywords:
GenotypeHepacivirusInterferonLiver transplantation

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