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Updated: Apr 9, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity
Jian Zhang1, Qingjun Liu1, Wallace Y Langdon2
1Department of Microbial Infection and Immunity, The Ohio State University, 460 West 12 Ave., Columbus, OH 43210.
Abstract:
Cbl-b is a member of the Cbl family of RING finger E3 ubiquitin ligases and polymorphisms and mutations in Cbl-b are associated with several autoimmune/inflammatory diseases in humans. Furthermore, gene targeting experiments in mice have provided proof of the in vivo effects of Cbl-b on T cell function and its involvement with these diseases. This brief review updates our understanding of Cbl-b in T cell tolerance, proallergic T cell development, and cancer immunity in light of the most recent advances, and their impact on autoimmune-/inflammatory diseases and cancer immunotherapy.
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