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Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits

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Conjunctival Short-term Evolution after Pterygium Excision.

Gemma Julio¹, Sara Lluch, Pere Pujol

¹*PhD †MD Ocular Surface Research Group, Optics and Optometry Department, Universitat Politècnica de Catalunya-Barcelona Tech, Terrassa, Barcelona, Spain (all authors); and Department of Ophthalmology, Consorci Sanitari de Terrassa-Hospital de Terrassa, Terrassa, Barcelona, Spain (PP).

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|June 18, 2015

Summary

Limbo-conjunctival autograft aids conjunctival recovery after pterygium excision. Adding mitomycin C (MMC) with autografting reduced goblet cell density less than other techniques, suggesting a good option to minimize pterygium recurrence.

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Area of Science:

Ophthalmology
Cell Biology
Surgical Techniques

Background:

Pterygium excision requires strategies to ensure conjunctival recovery and minimize recurrence.
Limbo-conjunctival autograft (LCA) is a common surgical approach.
The role of intraoperative mitomycin C (MMC) in conjunction with LCA on conjunctival cytology requires further investigation.

Purpose of the Study:

To analyze conjunctival cytological features one month after pterygium excision using LCA.
To compare outcomes with and without intraoperative mitomycin C (MMC).
To assess the short-term evolution of conjunctival tissue in both surgical scenarios.

Main Methods:

Fifty-nine primary nasal pterygia were excised using LCA.
Patients were divided into two groups: 29 treated with intraoperative mitomycin C 0.02% (MMC+) and 30 without (MMC-).
Impression cytology was performed pre- and post-surgery to quantify goblet cell density (GCD) and nucleus-to-cytoplasm ratio.

Main Results:

Post-surgery, nasal GCD was significantly lower in the MMC+ group compared to the MMC- group.
While nasal GCD decreased in the MMC+ group one month post-surgery, the reduction was less pronounced than previously reported with MMC alone.
No significant changes in GCD or nucleus-to-cytoplasm ratio were observed in the MMC- group or temporal conjunctiva in either group.

Conclusions:

Limbo-conjunctival autograft (LCA) facilitates early conjunctival recovery.
The combination of MMC with LCA resulted in a lower GCD reduction compared to other surgical techniques.
Optimized MMC concentration and exposure alongside LCA presents a viable clinical strategy for reducing pterygium recurrence.