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Updated: Apr 9, 2026

Measuring Oral Fatty Acid Thresholds, Fat Perception, Fatty Food Liking, and Papillae Density in Humans
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A Fat to Forget: Trans Fat Consumption and Memory.

Beatrice Alexandra Golomb1, Alexis K Bui1

  • 1Department of Medicine, University of California San Diego, La Jolla, California, United States of America.

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|June 18, 2015
PubMed
Summary

High intake of dietary trans fatty acids (dTFA) is linked to poorer word memory in younger adults. Reducing dTFA may support cognitive function and brain health.

Area of Science:

  • Nutrition Science
  • Cognitive Neuroscience
  • Public Health

Background:

  • Dietary trans fatty acids (dTFA) are linked to various adverse health outcomes.
  • Understanding the impact of dTFA on cognitive function, particularly memory, is crucial for public health.
  • Previous research has not fully elucidated the relationship between dTFA and specific cognitive domains like word memory.

Purpose of the Study:

  • To investigate the association between dietary trans fatty acid (dTFA) consumption and word memory performance.
  • To determine if this association differs across age groups.

Main Methods:

  • Cross-sectional analysis of data from the UCSD Statin Study (1999-2005) involving 1018 adults.
  • Dietary trans fatty acid (dTFA) intake estimated using the Fred Hutchinson Food Frequency Questionnaire.

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  • Regression analyses, stratified by age 45, examined the relationship between dTFA and word memory, with adjustments for potential confounders.

    • Main Results:

    • A significant interaction between age and dTFA consumption was observed.
    • Higher dTFA intake was significantly associated with poorer word recall specifically in younger adults.
    • Each gram/day increase in dTFA was linked to recalling approximately 0.76 fewer words, even after adjustments.

    Conclusions:

    • Increased dietary trans fatty acid (dTFA) consumption is associated with diminished word recall in younger adults.
    • Potential mediating factors include metabolic and anthropometric measures, suggesting complex pathways.
    • Findings suggest that reducing dTFA intake could be beneficial for preserving cognitive function, particularly memory, in younger populations.