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DC-SIGN: The Strange Case of Dr. Jekyll and Mr. Hyde
Juan J Garcia-Vallejo1, Yvette van Kooyk1
1Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam MF-B242, 1081BT, the Netherlands.
Immunity
|June 18, 2015
Abstract:
In this issue of Immunity, Conde et al. (2015) showed that a costimulatory blockade favors the accumulation of CD209a(+) macrophages which, upon interaction with fucosylated tissue ligands, promotes the expansion of CD4(+)Foxp3(+) Treg cell number.
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