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Hypolipidemic effects of nimesulide and celecoxib in experimentally induced hypercholesterolemia in rabbits

Sagheer Ahmed, Saima Gul, Muhammad Zia-ul-Haq

    Turkish Journal of Medical Sciences
    |June 19, 2015
    PubMed
    Abstract

    Insights

    Cyclooxygenase-2 (COX-2) inhibition may improve lipid profiles in hypercholesterolemia. Both celecoxib and nimesulide demonstrated lipid-lowering potential in rabbits with experimental hypercholesterolemia.

    Area of Science:

    • Cardiovascular Research
    • Pharmacology

    Background:

    • Hypercholesterolemia is a major risk factor for atherosclerotic disease, a leading global cause of mortality.
    • Cyclooxygenase (COX) inhibitors have shown potential in managing hypercholesterolemia.
    • The specific role of COX-2 in lipid metabolism and atherogenesis requires further elucidation.

    Purpose of the Study:

    • To investigate the effect of COX-2 inhibition on lipid profiles in a rabbit model of hypercholesterolemia.
    • To evaluate the lipid-lowering potential of celecoxib and nimesulide, selective COX-2 inhibitors.

    Main Methods:

    • Hypercholesterolemia was induced in rabbits via a high-cholesterol diet.
    • Rabbits were divided into four groups: control, hypercholesterolemic (saline-treated), and hypercholesterolemic treated with celecoxib or nimesulide.
    • Serum lipid levels, including total cholesterol, HDL, LDL, and triglycerides, were monitored.

    Main Results:

    • Hypercholesterolemic rabbits exhibited significantly elevated cholesterol, LDL, and triglycerides, with reduced HDL levels.
    • Treatment with celecoxib and nimesulide led to notable improvements in lipid profiles compared to saline-treated controls.
    • These findings suggest a role for COX-2 in the progression of hypercholesterolemia.

    Conclusions:

    • COX-2 inhibition, exemplified by celecoxib, may play a beneficial role in managing hypercholesterolemia and mitigating atherogenesis.
    • The lipid-modifying effects of nimesulide and celecoxib might extend beyond COX-2 inhibition.
    • Both agents show promise as therapeutic options for experimental hypercholesterolemia.

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