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The effects of atorvastatin on antioxidant/antiinflammatory properties of HDLs in hypercholesterolemics

Gülşen Akalin Çiftçi, İpek Ertorun, Aysen Akalin

    Turkish Journal of Medical Sciences
    |June 19, 2015
    PubMed

    Insights

    Atorvastatin treatment improved endothelial function and reduced oxidative stress in hypercholesterolemic patients. The study highlights atorvastatin

    Area of Science:

    • Cardiovascular Medicine
    • Pharmacology

    Background:

    • Hypercholesterolemia impacts lipid profiles, nitric oxide pathways, and oxidative stress.
    • High-density lipoprotein (HDL) function in hypercholesterolemia treated with atorvastatin requires further elucidation.

    Purpose of the Study:

    • To assess atorvastatin's effects on HDL functionality in hypercholesterolemic individuals.
    • To evaluate changes in oxidative stress and endothelial function markers post-atorvastatin treatment.

    Main Methods:

    • Thirty hypercholesterolemic patients (40-60 years) received 10 mg/day atorvastatin for 3 months.
    • Endothelial function markers (ADMA, homocysteine, NO) and oxidative stress markers (MDA, AOP, PON1, arylesterase) were measured.
    • Lipid profiles and HDL antioxidant/anti-inflammatory levels were assessed pre- and post-treatment.

    Main Results:

    • Atorvastatin decreased ADMA and homocysteine, increasing nitric oxide levels.
    • Malondialdehyde levels decreased, while antioxidant potential, PON1, arylesterase, and anti-inflammatory HDL characteristics increased.
    • Significant improvements in patient lipid profiles were observed.

    Conclusions:

    • Hypercholesterolemia is linked to oxidative stress, endothelial dysfunction, and pro-inflammatory HDL.
    • Atorvastatin effectively modulates HDL anti-inflammatory properties, endothelial function, and oxidative status.
    • Findings suggest pleiotropic benefits of atorvastatin in mitigating atherosclerosis progression.
    Abstract

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