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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

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[Advance in studies on anti-cancer activity and mechanism of flavonoids]

Nan Yang, Xiao-bin Jia, Zhen-hai Zhang

    Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
    |June 19, 2015
    PubMed

    Insights

    Flavonoids, natural compounds with low toxicity, show significant anti-cancer effects against various tumors. Their mechanisms involve antioxidant properties, apoptosis induction, and cell cycle regulation, offering potential for cancer treatment.

    Area of Science:

    • Natural Products Chemistry
    • Pharmacology
    • Oncology

    Context:

    • Flavonoids are widely distributed natural products known for diverse physiological activities and minimal toxicity.
    • Growing research interest focuses on the anti-tumor potential of flavonoids in various cancer types.
    • Existing studies highlight the efficacy of flavonoids in preventing and treating lung, breast, colon, and liver cancers, among others.

    Purpose:

    • To review and synthesize recent domestic and international research on the anti-cancer activity of flavonoids.
    • To elucidate the multifaceted mechanisms underlying the anti-tumor effects of flavonoids.
    • To provide a theoretical foundation and research directions for the clinical application of flavonoids in cancer therapy.

    Summary:

    • Flavonoids exhibit potent anti-cancer properties against a broad spectrum of malignancies, including lung, breast, colon, prostate, liver, leukemia, ovarian, and gastric cancers.
    • Key anti-tumor mechanisms include antioxidant and anti-free radical activities, induction of cancer cell apoptosis, cell cycle modulation, immune regulation, and inhibition of tumor angiogenesis, COX-2, and telomerase.
    • This review consolidates current knowledge on flavonoid anti-cancer actions and mechanisms.

    Impact:

    • Highlights the therapeutic potential of flavonoids as natural anti-cancer agents.
    • Offers insights into the molecular mechanisms of flavonoid-induced cancer cell death and growth inhibition.
    • Provides a basis for developing novel flavonoid-based cancer prevention and treatment strategies.

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