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Related Experiment Video

Updated: Apr 9, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
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Reduced Baroreflex Sensitivity in Cluster Headache Patients.

Mads C J Barloese1,2, Jesper Mehlsen1, Louise Brinth1

  • 1Department of Clinical Physiology and Nuclear Medicine, Frederiksberg and Bispebjerg Hospital, University of Copenhagen, Frederiksberg, Denmark.

Headache
|June 19, 2015
PubMed
Summary

Cluster headache patients show reduced baroreflex sensitivity (BRS), indicating autonomic nervous system dysfunction. This blunting may be influenced by recent cluster headache attacks, suggesting a link between attacks and autonomic control.

Keywords:
autonomic dysfunctionbaroreflexcluster headachehypothalamuspain

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Area of Science:

  • Neurology
  • Autonomic Neuroscience
  • Cardiovascular Physiology

Background:

  • Cluster headache (CH) pathophysiology may involve the posterior hypothalamus.
  • Cranial autonomic features are characteristic of CH, but systemic autonomic control involvement is debated.

Purpose of the Study:

  • To investigate autonomic function in CH patients by assessing baroreflex sensitivity (BRS).

Main Methods:

  • Twenty-six active CH patients and 26 matched controls underwent head-up tilt table testing.
  • Baroreflex sensitivity (BRS) was determined using the sequence method.

Main Results:

  • CH patients exhibited blunted RR interval reactivity to blood pressure changes compared to controls.
  • BRS was significantly lower in CH patients who had experienced an attack within 12 hours.
  • A higher drop in systolic blood pressure was observed in recent attack sufferers during tilting.

Conclusions:

  • CH patients display subclinical baroreflex sensitivity (BRS) blunting, potentially exacerbated by recent attacks.
  • This suggests parasympathetic nervous system dysfunction or impaired central baroreceptor impulse relay in CH.
  • The findings highlight a potential role for autonomic dysfunction in cluster headache pathophysiology.