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Updated: Apr 9, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Cobalt-Catalyzed Cross-Benzannulation of Conjugated Enynes and Diynes
Philipp Röse1, Carmen Carlota Magraner Garcia1, Florian Pünner1
1Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße 4, D-35043 Marburg, Germany.
Abstract:
The [4 + 2] cross-benzannulation of conjugated enynes and diynes under cobalt-catalysis led to 1,2,3-trisubstituted benzene derivatives in good yields. The reaction proceeds smoothly in absolute regiospecific control when symmetrical diynes are applied. Moreover, the use of unsymmetrical diynes was investigated, resulting in the formation of the unprecedented regioisomers as major products, which is in contrast to the results obtained in palladium-catalyzed benzannulation reactions. Also, 4-bromophenyl-substituted starting materials could be applied successfully in the cobalt-catalyzed process, which can be problematic in the palladium-catalyzed counterpart.
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