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Solid-phase synthesis of oligoribonucleotides
1Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
Nucleic Acids Symposium Series
|January 1, 1989
Abstract:
An efficient method is described for solid-phase synthesis of oligoribonucleotides that involves use of the 9-fluorenylmethoxycarbonyl group (Fmoc) for 5'-protection, 4-methoxytetrahydropyran-4-yl (Mthp) for 2'-protection and a phosphoramidite coupling procedure.