Synthesis of 2'-deoxy-6,2'-methano-pyrimidine nucleosides and optical properties of pyrimidine C-cyclonucleosides
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Y Yoshimura1, A Matsuda, T Ueda
1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Nucleic Acids Symposium Series
|January 1, 1989
Abstract:
2'-Deoxy-6,2'-methano derivatives of uridine, cytidine, and 4-thiouridine were synthesized by the Peterson olefination of a ketosugar with a pyrimidine followed by an intramolecular glycosylation reaction. CD-spectra of these cyclonucleosides together with other pyrimidine C-cyclonucleosides were given.