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Lead Assessment in Biological Samples of Children with Different Gastrointestinal Disorders

Faheem Shah1,2, Naeem Ullah3, Tasneem Gul Kazi4

  • 1Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan. shah_ceac@yahoo.com.

Biological Trace Element Research
|June 19, 2015
PubMed

Insights

Children with gastrointestinal disorders show elevated lead (Pb) levels in biological samples compared to healthy children. This study highlights potential environmental health risks associated with pediatric digestive issues.

Area of Science:

  • Environmental Health
  • Pediatric Gastroenterology
  • Analytical Chemistry

Background:

  • Pediatric gastrointestinal disorders are a significant health concern.
  • Lead exposure is a known environmental toxin with widespread health implications.
  • Understanding the link between lead levels and pediatric health is crucial.

Purpose of the Study:

  • To evaluate and compare lead (Pb) levels in biological samples of children with gastrointestinal disorders versus healthy children.
  • To determine if elevated lead levels correlate with pediatric gastrointestinal conditions.

Main Methods:

  • Analysis of biological samples (blood, scalp hair, urine) from children aged 4-10 years.
  • Microwave digestion of samples followed by lead determination using graphite furnace atomic absorption spectrometry (GFAAS).
  • Comparison of lead levels between children with gastrointestinal disorders and age-matched healthy controls.

Main Results:

  • Significant differences in lead profiles were observed between diseased and healthy children.
  • Diseased children exhibited elevated lead content exceeding World Health Organization (WHO) permissible limits.
  • Healthy children showed lead levels within normal, permissible ranges.

Conclusions:

  • Children experiencing gastrointestinal disorders may have higher lead exposure.
  • Elevated lead levels in children warrant further investigation into environmental factors and potential health impacts.
  • This study underscores the importance of monitoring lead exposure in vulnerable pediatric populations.

Keywords:
Biological samplesChildrenGastrointestinalLeadReferents

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