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Published on: June 30, 2022
Expression of Pattern Recognition Receptors by Nociceptive Metasympathetic Neurons
L V Filippova1, E Yu Bystrova, F S Malyshev
1I. P. Pavlov Institute of Physiology, Russian Academy of Medical Sciences, St. Petersburg, Russia, lvfil@yandex.ru.
Abstract:
Immunohistochemical assay with double label and confocal laser scanning microscopy showed that innate immunity receptor TLR4 is expressed predominantly in neurons of the intestinal Auerbach (myenteric) plexus, while vanilloid nociceptive receptor TRPV1 is expressed by neurons of Meissner (submucous) plexus. Immunohistochemical analysis with triple labeling revealed coexpression of TLR4 and TRPV1 in enteric neurons of rat colon. The results attest to a possibility of functional interaction between Toll-like and vanilloid receptors in the neuron level.
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