Related Experiment Video

Updated: Jun 23, 2026

Method for Obtaining Primary Ovarian Cancer Cells From Solid Specimens
05:58

Method for Obtaining Primary Ovarian Cancer Cells From Solid Specimens

Published on: February 4, 2014

14.3K

Circulating Biomarkers and Abdominal Aortic Aneurysm Incidence: The Atherosclerosis Risk in Communities (ARIC) Study

Aaron R Folsom1, Lu Yao2, Alvaro Alonso2

  • 1From Division of Epidemiology and Community Health, School of Public Health (A.R.F., L.Y., A.A., P.L.L., W.T.), Division of Cardiology, Department of Medicine, School of Medicine (E.M.), and Department of Medicine, School of Medicine (F.A.L.), University of Minnesota, Minneapolis; Minneapolis VA Health Care System, MN (F.A.L.); and Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine and Center for Cardiovascular Disease Prevention, Houston Methodist DeBakey Heart and Vascular Center, TX (C.M.B.). folso001@umn.edu.

Circulation
|June 19, 2015
PubMed

Insights

Six blood biomarkers predict abdominal aortic aneurysm (AAA) risk. Higher concentrations and more identified markers significantly increase the likelihood of developing AAA, identifying high-risk individuals.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Epidemiology

Background:

  • Abdominal aortic aneurysm (AAA) pathogenesis is complex.
  • Cross-sectional studies suggest links between circulating biomarkers and AAA.
  • Prospective evidence for these associations is limited.

Purpose of the Study:

  • To investigate the prospective association between multiple blood biomarkers and incident AAA.
  • To identify specific biomarkers and their cumulative effect on AAA risk.

Main Methods:

  • Prospective cohort study (Atherosclerosis Risk in Communities Study).
  • Measured blood biomarkers of inflammation, hemostasis, cardiac function, and vascular stiffness.
  • Identified incident AAA using hospital discharge codes during follow-up.

Main Results:

  • Six biomarkers (white blood cell count, fibrinogen, D-dimer, troponin T, N-terminal pro-brain natriuretic peptide, high-sensitivity C-reactive protein) were positively associated with AAA incidence.
  • Increasing numbers of these biomarkers in the highest quartile were associated with significantly higher AAA risk (HRs 2.2 to 9.9).
  • A strong trend (P < 0.0001) was observed after adjusting for other risk factors.

Conclusions:

  • Higher concentrations of these six biomarkers are prospectively associated with increased AAA risk.
  • A cumulative effect exists: more biomarkers in the highest quartile correlate with greater AAA risk.
  • Identifying individuals with multiple positive biomarkers can define a high-risk subgroup for AAA.
Abstract

Keywords:
aortic aneurysm, abdominalcohort studiesrisk factors

More Related Videos

Labeling of Extracellular Vesicles for Monitoring Migration and Uptake in Cartilage Explants07:58

Labeling of Extracellular Vesicles for Monitoring Migration and Uptake in Cartilage Explants

Published on: October 4, 2021

3.3K
Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

5.4K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...