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Heart Failure in Chronic Myocarditis: A Role for microRNAs?
P van den Hoogen1, F van den Akker2, J C Deddens2
1Department of Cardiology, University Medical Center Utrecht, the Netherlands; ; ICIN - Netherlands Heart Institute, Utrecht, The Netherlands.
Current Genomics
|June 19, 2015
Summary
MicroRNAs (miRNAs) show altered expression during chronic myocarditis, potentially leading to heart failure. Understanding these changes may offer new diagnostic and therapeutic strategies for myocarditis.
Area of Science:
- Cardiology
- Molecular Biology
- Genetics
Background:
- Myocarditis is a heart inflammation that can lead to chronic damage and heart failure.
- During chronic myocarditis, ongoing inflammation damages heart cells, causing dilated cardiomyopathy and reduced function.
- MicroRNAs (miRNAs), small non-coding RNAs, exhibit altered expression patterns during myocarditis progression.
Purpose of the Study:
- To review the natural course of myocarditis and its progression to heart failure.
- To discuss current knowledge of miRNA expression alterations in chronic myocarditis.
- To explore potential miRNA-based diagnostic and therapeutic interventions for myocarditis.
Main Methods:
- Literature review focusing on myocarditis progression and miRNA expression.
- Analysis of existing studies on miRNA alterations in acute and chronic myocarditis.
- Exploration of preclinical data on miRNA-based interventions in cardiovascular diseases.
Main Results:
- Chronic myocarditis involves persistent inflammation and cardiomyocyte loss, progressing to heart failure.
- Specific miRNA expression changes observed in acute myocarditis may persist into the chronic phase.
- miRNA-based strategies show promise in preclinical models for cardiovascular diseases.
Conclusions:
- Altered miRNA expression in chronic myocarditis presents potential as diagnostic biomarkers.
- miRNA-based therapies could offer novel treatment options to prevent heart failure progression in myocarditis patients.
- Further research into miRNA roles is crucial for developing effective myocarditis interventions.
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