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Modeling and Imaging 3-Dimensional Collective Cell Invasion
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Cancer Invasion: Patterns and Mechanisms.

N V Krakhmal1, M V Zavyalova2, E V Denisov3

  • 1Siberian State Medical University, Moskovskiy Trakt, 2, 634050, Tomsk, Russia.

Acta Naturae
|June 19, 2015
PubMed
Summary

Cancer cells migrate individually or collectively, using mesenchymal or amoeboid movement. Understanding these invasion patterns is key to cancer progression and treatment efficacy.

Keywords:
cancercell migrationcollective cell migrationindividual cell migrationinvasion

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Area of Science:

  • Oncology
  • Cell Biology
  • Cancer Research

Background:

  • Cancer cell invasion and metastasis are critical factors in tumor progression and patient outcomes.
  • Two primary modes of cancer cell invasion, collective and individual cell migration, have been identified.
  • These migration patterns involve distinct morphological features and underlying molecular mechanisms.

Purpose of the Study:

  • To review the key differences between variants of cancer cell migration.
  • To explore the role of epithelial-mesenchymal, collective-amoeboid, mesenchymal-amoeboid, and amoeboid-mesenchymal transitions in tumor invasion.
  • To highlight the significance of tumor and stromal factors in cancer invasion and progression.

Main Methods:

  • Literature review of existing studies on cancer cell migration patterns.
  • Analysis of morphological and molecular genetic mechanisms of collective and individual cell migration.
  • Presentation of original research data linking breast cancer progression to intratumoral heterogeneity and cell migration types.

Main Results:

  • Cancer cell migration occurs through mesenchymal (fibroblast-like) or amoeboid phenotypes within both collective and individual migration patterns.
  • Transitions between these migratory states (e.g., epithelial-mesenchymal transition) are crucial for invasion.
  • Intratumoral morphological heterogeneity in breast cancer is associated with progression and reflects different cancer cell migration activities and cell adhesion molecule expression.

Conclusions:

  • Understanding the distinct patterns and transitions of cancer cell migration is essential for comprehending cancer progression.
  • Morphological variations within tumors indicate different cell migration strategies and are linked to disease advancement.
  • The study of cell migration patterns and associated molecular factors offers insights into improving cancer therapy efficacy.