Shear Wave Elastography of Focal Liver Lesion: Intraobserver Reproducibility and Elasticity Characterization

The aim of the study was to evaluate the intraobserver reproducibility and to determine the elasticity characteristics of focal liver lesions (FLLs) by shear wave elastography (SWE).

One hundred thirty-six FLLs in 118 patients were examined with SWE for quantitative and qualitative assessment of stiffness. Three SWE images were obtained for each lesion and liver parenchyma by 1 radiologist. Intraobserver reproducibility was assessed by intraclass correlation coefficients (ICCs). Patient and lesion factors that can affect the reproducibility were evaluated. For characterization of the lesion elasticity, the difference in stiffness between the groups of lesions was evaluated.

The mean (SD) diameter and depth of the lesions were 3.98 (2.07) and 4.4 (1.59) cm, respectively. The ICC of intraobserver reproducibility was 0.763. Deep-seated lesions (≥6 cm; ICC, 0.621) showed significantly lower intraobserver reproducibility compared with superficial lesions (ICC, 0.793; P = 0.047). Stiffness values of malignant lesions (n = 85, 60.41 [47.81] kPa) were significantly higher than those of benign lesions (n = 51, 22.05 [17.24] kPa, P < 0.0001). Mean (SD) stiffness of hepatocellular carcinoma (45.72 [35.65] kPa) was significantly lower than that of metastasis (67.43 [43.39] kPa) and was significantly higher than benign FLLs (22.05 [17.24] kPa). However, mean (SD) lesion-parenchyma ratio of hepatocellular carcinoma (3.76 [4]) was not significantly different from that of benign FLLs (3.7 [3.77]).

Overall, intraobserver reproducibility of SWE in evaluation of FLLs was excellent, but it can be affected by lesion depth. In addition, SWE is helpful in elasticity characterization of FLLs.