Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Valves01:16

Heart Valves

15.3K
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
15.3K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.7K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.7K
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

1.6K
The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
1.6K
Overview of Systemic and Pulmonary Circulation01:15

Overview of Systemic and Pulmonary Circulation

14.3K
The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
14.3K
Physiology of the Heart: The Cardiac Cycle01:18

Physiology of the Heart: The Cardiac Cycle

14.4K
The cardiac cycle describes the events from one heartbeat to the next. It includes three main phases: diastole, atrial systole, and ventricular systole, all driven by changes in chamber pressures and the function of heart valves.
Diastole: The Relaxation Phase
During diastole, all four heart chambers relax. The atrioventricular (AV) valves open, and the semilunar valves close. This phase sees the lowest chamber pressures, promoting ventricular filling. Venous blood enters the heart through the...
14.4K
Coronary Circulation01:21

Coronary Circulation

9.6K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
9.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of LVOT Gradient and LA Strain with Cardiac Events in Pediatric HCM.

Pediatric cardiology·2026
Same author

Intraoperative Hypotension in Children Undergoing Noncardiac Surgery: An Exploratory Single-Center Analysis of Incidence, Associated Risk Factors, and Outcomes.

Anesthesia and analgesia·2026
Same author

Influence of multiple trauma on the effect of transfusion strategies in patients with traumatic brain injury: a sub-study of the HEMOTION trial.

Intensive care medicine·2026
Same author

Association of Perinatal HIV Exposure and HIV Disease Severity With BP in Youth.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Evaluating Functional Imagery Training and Internal Visual Imagery on Tennis Serve Performance.

Journal of sport & exercise psychology·2026
Same author

Self-guided functional imagery training to reduce anxiety.

Behaviour research and therapy·2026
Same journal

Incomplete Recovery of Diaphragmatic Mechanics at a Train-of-Four Ratio of 0.90 to <0.95 Assessed by Dynamic Digital Radiography: A Proof-of-Concept Case Series.

Anesthesia and analgesia·2026
Same journal

Patients' Perspectives and Experiences of Participating in Anesthesia Research: A Qualitative Study.

Anesthesia and analgesia·2026
Same journal

Impact of Epidural-Related Maternal Fever on Neonatal Outcomes: A Single-Center Retrospective Case-Control Study Excluding Confirmed Histological Chorioamnionitis.

Anesthesia and analgesia·2026
Same journal

Patient Beliefs and Experiences of Adhering to Medical Therapies for Cardiovascular Comorbidities, Before Noncardiac Elective Surgery in South Africa: A Mixed-Methods Study.

Anesthesia and analgesia·2026
Same journal

Beyond Administrative Indices: Allostatic Load and Autonomic Dyshomeostasis as Biological Mediators of Intraoperative Cardiac Arrest.

Anesthesia and analgesia·2026
Same journal

In Response.

Anesthesia and analgesia·2026
See all related articles

Related Experiment Video

Updated: Apr 9, 2026

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring
06:29

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

Published on: May 2, 2025

917

Fontan physiology revisited.

Matthew Jolley1, Steven D Colan, Jonathan Rhodes

  • 1From the Department of Pediatric Cardiac Anesthesia, Boston Children's Hospital, Boston, Massachusetts; and Department of Pediatric Cardiology, Boston Children's Hospital, Boston, Massachusetts.

Anesthesia and Analgesia
|June 19, 2015
PubMed
Summary
This summary is machine-generated.

The Fontan operation, a surgery for single-ventricle congenital heart disease, series circulations. This review covers the physiological changes and intensive care implications of this Fontan anatomy.

More Related Videos

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.2K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.4K

Related Experiment Videos

Last Updated: Apr 9, 2026

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring
06:29

Wireless Telemetry Device Implantation in a Fontan Ovine Model for Continuous and Long-Term Hemodynamic Monitoring

Published on: May 2, 2025

917
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.2K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.4K

Area of Science:

  • Cardiology
  • Pediatric Surgery
  • Anesthesiology

Background:

  • The Fontan operation is a surgical procedure for single-ventricle congenital heart disease.
  • It creates a series connection between systemic and pulmonary circulations, powered by a single ventricle.

Purpose of the Study:

  • To review the physiological changes resulting from Fontan anatomy.
  • To discuss implications for anesthetic and intensive care management.

Main Methods:

  • Literature review of the physical basis of physiological changes after Fontan operation.
  • Analysis of cardiovascular and respiratory system alterations.
  • Examination of sequelae relevant to critical care.

Main Results:

  • Fontan circulation significantly alters cardiovascular dynamics.
  • Respiratory system function is also profoundly affected.
  • These changes necessitate specialized anesthetic and intensive care approaches.

Conclusions:

  • Understanding the unique physiology post-Fontan operation is crucial.
  • Anesthetic and intensive care strategies must address these specific physiological alterations.
  • Optimized management improves outcomes for patients with single-ventricle congenital heart disease.