Related Experiment Video
Updated: Apr 9, 2026
Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
Published on: August 26, 2014
Central Reading of Endoscopy Endpoints in Inflammatory Bowel Disease Trials
Klaus Gottlieb1, Simon Travis, Brian Feagan
1*Gastroenterology Center of Excellence, Quintiles, Durham, North Carolina; †Translational Gastroenterology Unit, Oxford University Hospitals, Oxford, United Kingdom; ‡Robarts Research Institute, Western University, London, ON, Canada; §Division of Gastroenterology, University of California San Diego, San Diego, California; and ||Division of Translational Research in Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.
Background:
Central reading of endoscopy (CROE) is crucial in determining who qualifies for a trial but also has a role, independent of the selected scoring system, in decreasing measurement noise that can obscure separation between placebo and active drug. Benefits of CROE may not be independent of the method chosen, and controversy exists about the ideal approach.
Methods:
Literature review and concept development.
Results:
Components to be considered in the reading algorithm are blinding, number of central readers, independent voting versus consensus panel, video recordings versus still images, and involvement of the site reader. Key concepts considered are endpoints, bias, power, and sample size derived from the Food and Drug Administration and European Medicines Agency guidelines, as well as the technological requirements and recruitment, qualification, and revalidation of central readers as applied to CROE.
Conclusions:
Recording and CROE should be standardized, and an imaging charter developed with research on the different components and its overall impact.
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