Task positive and default mode networks during a working memory in children with primary monosymptomatic nocturnal
Kaihua Zhang1, Jun Ma2, Du Lei1,3
1Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
Insights
Children with primary monosymptomatic nocturnal enuresis (PMNE) show brain differences in working memory tasks. These findings suggest potential working memory dysfunction in children experiencing bedwetting.
Area of Science:
- Neuroscience
- Pediatrics
- Developmental Psychology
Background:
- Primary monosymptomatic nocturnal enuresis (PMNE) is a prevalent developmental disorder in children.
- PMNE is the most common subtype of nocturnal enuresis.
Purpose of the Study:
- To investigate brain functional abnormalities related to working memory in children with PMNE.
- To compare brain activity during a working memory task between children with PMNE and healthy controls.
Main Methods:
- Functional magnetic resonance imaging (fMRI) was used in conjunction with an n-back task.
- Twenty children with PMNE and 20 age- and sex-matched healthy children participated.
Main Results:
- Children with PMNE displayed reduced activation in brain regions like the right precentral gyrus and right inferior parietal lobule.
- Decreased task-positive network activation and increased default mode network deactivation were observed in children with PMNE.
- Longer response times were noted in the PMNE group during the working memory task.
Conclusions:
- Children with PMNE exhibit distinct brain response patterns during working memory tasks.
- Greater default mode network deactivation may be a compensatory mechanism for working memory function in PMNE.
- The study suggests potential working memory dysfunction in children with PMNE.
Background:
Nocturnal enuresis is a common developmental disorder in children, and primary monosymptomatic nocturnal enuresis (PMNE) is the dominant subtype.
Methods:
This study investigated brain functional abnormalities that are specifically related to working memory in children with PMNE using function magnetic resonance imaging (fMRI) in combination with an n-back task. Twenty children with PMNE and 20 healthy children, group-matched for age and sex, participated in this experiment.
Results:
Several brain regions exhibited reduced activation during the n-back task in children with PMNE, including the right precentral gyrus and the right inferior parietal lobule extending to the postcentral gyrus. Children with PMNE exhibited decreased cerebral activation in the task-positive network, increased task-related cerebral deactivation during a working memory task, and longer response times.
Conclusion:
Patients exhibited different brain response patterns to different levels of working memory and tended to compensate by greater default mode network deactivation to sustain normal working memory function. Our results suggest that children with PMNE have potential working memory dysfunction.
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